| Title | Effects of three metabolites of propiverine on voltage-dependent L-type calcium currents in human atrial myocytes. | | Author(s) | Wuest M, Christ T, Hiller N, Braeter M, Ravens U | | Institution | Department of Pharmacology and Toxicology, Dresden University of Technology, Dresden, Germany. melinda.wuest@tu-dresden.de | | Source | Eur J Pharmacol 2008 Nov 19; 598(1-3):94-7. | | MeSH | Benzilates
Calcium Channel Blockers
Calcium Channels, L-Type
Cell Separation
Coronary Artery Bypass
Dose-Response Relationship, Drug
Heart Atria
Humans
Membrane Potentials
Myocytes, Cardiac
Nisoldipine
| | Abstract | The non-selective muscarinic receptor antagonist propiverine impairs L-type Ca(2+) currents (I(Ca,L)) in human detrusor smooth muscle cells and atrial cardiomyocytes. Here, we have investigated the effects of three metabolites of propiverine on human cardiac I(Ca,L). Propiverine reduced I(Ca)(,L) with a -logIC(50) [M] value of 4.1, M-5 only showed minor effect on I(Ca)(,L) at high concentrations, M-6 did not influence I(Ca)(,L) at all. Like the parent compound M-14 also reduced I(Ca)(,L) (-logIC(50) [M]=4.6). We conclude, that propiverine and M-14 reduce cardiac I(Ca)(,L) at higher concentrations than in detrusor cells and therefore preferentially reduce I(Ca)(,L) in the urinary bladder than in the heart. | | Language | eng | | Pub Type(s) | In Vitro
Journal Article
| | PubMed ID | 18796302 |
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