| Title | Nicotine aerosol generation from thermally reversible zinc halide complexes using the staccato(r) system. | | Author(s) | Simis K, Lei M, Lu AT, Sharma KC, Hale RL, Timmons R, Cassella J | | Institution | Alexza Pharmaceuticals, Chemical Research, Mountain View, CA, USA. | | Source | Drug Dev Ind Pharm 2008 Sep; 34(9):936-42. | | Abstract | Application of the Staccato system to liquid drugs presents unique technological challenges. Liquids, such as nicotine, do not form physically stable films on vaporization substrates. We identified two thermally reversible zinc halides (ZnCl(2) and ZnBr(2)) that complex with nicotine in a 1:2 mol ratio (zinc halide: nicotine) that can be coated as a solid film. Feasibility studies indicated that the chloride complex liberates a higher fraction of nicotine upon heating whereas the nicotine aerosol purity for both complexes was approximately 99%. Using a multidose Staccato device previously used in a Phase I clinical trial, we demonstrated that highly pure nicotine aerosol can be reliably generated from the chloride complex with the following qualities: aerosol purity approximately 99%, single emitted dose approximately 117 mug, particle fraction approximately 57%, and mean particle size approximately 0.8 mum. These results were supported by thermogravimetric analysis and differential scanning calorimetry. | | Language | eng | | Pub Type(s) | Journal Article
| | PubMed ID | 18800254 |
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