Pneumococcal meningitis during antiviral treatment with interferon and ribavirin in a splenectomized patient with chronic hepatitis C - do not miss vaccination before starting therapy. Zeitschrift für Gastroenterologie [Z Gastroenterol] Journal article | | Title | Pneumococcal meningitis during antiviral treatment with interferon and ribavirin in a splenectomized patient with chronic hepatitis C - do not miss vaccination before starting therapy. | | Author(s) | Hadem J, Cornberg M, Hauptmann C, Süttmann U, Manns MP, Wedemeyer H | | Institution | Department of Gastroenterology, Hepatology and Endocrinology, Medical School Hannover, Carl-Neuberg-Str. 1,30625 Hannover, Germany. hadem.johannes@mhhannover.de | | Source | Z Gastroenterol 2008 Sep; 46(9):880-2. | | MeSH | Adult
Antiviral Agents
Bacterial Proteins
Cefotaxime
Dose-Response Relationship, Drug
Drug Therapy, Combination
Follow-Up Studies
Hearing Loss, Unilateral
Hepatitis C, Chronic
Humans
Infusions, Intravenous
Interferon Type I, Recombinant
Male
Meningitis, Pneumococcal
Opportunistic Infections
Penicillin G
Pneumococcal Vaccines
Randomized Controlled Trials as Topic
Ribavirin
Risk Factors
Splenectomy
| | Abstract | We report on a 35-year-old man who developed pneumococcal meningitis while receiving antiviral therapy with interferon (consensus interferon, CIFN) and ribavirin for chronic hepatitis C. Antibiotic therapy was started four days after the onset of symptoms. Unfortunately, the patient developed a persisting right-sided cochlear hearing impairment. Antiviral therapy led to sustained viral response of hepatitis C. At the age of 14 years he had experienced a hemorrhagic shock after a traffic accident, received multiple blood transfusions and undergone a splenectomy. He had not received vaccination against Streptococcus pneumoniae. This case report reminds us that splenectomized patients without previous pneumococcal vaccination should receive such vaccination before immunomodulatory treatment. | | Language | eng | | Pub Type(s) | Case Reports
Journal Article
| | PubMed ID | 18810674 |
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