| Title | Mortality from thyroid cancer in patients with hyperthyroidism: The Theagenion Cancer Hospital experience. | | Author(s) | Pazaitou-Panayiotou K, Perros P, Boudina M, Siardos G, Drimonitis A, Patakiouta F, Vainas I | | Institution | K Pazaitou-Panayiotou, Department of Endocrinology-Endocrine Oncology, Theagenio Cancer Hospital, Thessaloniki, 54007, Greece. | | Source | Eur J Endocrinol 2008 Sep 26. | | Abstract | Abstract
Background: Thyroid carcinoma has been reported in patients operated for different types of hyperthyroidism and the probability of a hot nodule being malignant seems to be low. The aim of the present study was to explore the relationship between thyroid cancer, hyperthyroid-ism and outcome in a large cohort of patients who presented to a tertiary cancer centre in Northern Greece.
Patients: Among 720 patients treated for thyroid cancer, 60 had a concomi-tant diagnosis of hyperthyroidism due to Graves disease (n=14), solitary autonomous ade-noma (n=17), or multinodular goiter (n=29). Adverse prognostic factors were common in pa-tients with a previous history of hyperthyroidism at the time of diagnosis of thyroid cancer, including cases where the cancer was discovered coincidentally after thyroid surgery for hy-perthyroidism and cases where tumor size was >10mm.
Results: In 10 of 17 patients with hy-perthyroidism due to solitary autonomous adenomas, the tumor was located within the hot nodule and two of these patients developed local and distant metastases and died from the disease 4 and 15 years after thyroidectomy.
Conclusion: Clinicians managing patients with hyperthyroidism need to be aware of the possible increased risk of thyroid cancer in this pa-tient group. | | Language | ENG | | Pub Type(s) | JOURNAL ARTICLE
| | PubMed ID | 18819945 |
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