Cutting edge: Inhibition of NF-kappaB-mediated TSLP expression by retinoid X receptor. Journal of immunology (Baltimore, Md. : 1950) [J Immunol] Journal article

Title	Cutting edge: Inhibition of NF-kappaB-mediated TSLP expression by retinoid X receptor.
Author(s)	Lee HC, Headley MB, Iseki M, Ikuta K, Ziegler SF
Institution	Immunology Program, Benaroya Research Institute, Seattle, WA 98101, USA.
Source	J Immunol 2008 Oct 15; 181(8):5189-93.
MeSH	Antineoplastic Agents Cell Line Cytokines Epithelial Cells Gene Expression Regulation Humans Inflammation Interleukin-1beta NF-kappa B Promoter Regions (Genetics) Respiratory Hypersensitivity Respiratory Mucosa Retinoid X Receptors Signal Transduction Tretinoin
Abstract	The epithelial-derived cytokine thymic stromal lymphopoietin (TSLP) has important roles in the initiation of allergic airway inflammation and the activation of dendritic cells. We have shown that the human TSLP gene is regulated in a NF-kappaB-dependent manner; however the factors that negatively regulate TSLP expression are not known. In this study we demonstrate that 9-cis-retinoic acid (9-cis-RA) is a negative regulator of TSLP expression in airway epithelial cells. This inhibition is manifested as a block in the IL-1beta-mediated recruitment of NF-kappaB to the human TSLP promoter. 9-cis-RA-mediated inhibition is not restricted to TSLP gene expression but rather reflects a general inhibition of NF-kappaB activation, as other NF-kappaB-regulated-genes were also inhibited in a similar manner by 9-cis-RA treatment. Taken as a whole, these data demonstrate that inhibition of IL-1beta-dependent genes by active retinoid X receptors involves antagonism of NF-kappaB signaling.
Language	eng
Pub Type(s)	Journal Article Research Support, N.I.H., Extramural
PubMed ID	18832669

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