| Title | Nifekalant and disopyramide in a patient with short QT syndrome: evaluation of pharmacological effects and electrophysiological properties. | | Author(s) | Mizobuchi M, Enjoji Y, Yamamoto R, Ono T, Funatsu A, Kambayashi D, Kobayashi T, Nakamura S | | Institution | Cardiovascular Center, Kyoto-Katsura Hospital, Kyoto, Japan. kcvc.mizobuchi@katsura.com | | Source | Pacing Clin Electrophysiol 2008 Sep; 31(9):1229-32. | | MeSH | Anti-Arrhythmia Agents
Atrial Fibrillation
Body Surface Potential Mapping
Disopyramide
Humans
Male
Pyrimidinones
Syndrome
Tachycardia, Ventricular
Treatment Outcome
Young Adult
| | Abstract | We assessed several pharmacological effects on electrocardiogram parameters and effective refractory period (ERP) in a patient with a short QT syndrome (SQTS). Pharmacological challenge tests revealed that disopyramide and selective I(kr) blocker, nifekalant normalized QT interval, and ERP of the atrial and ventricular myocardium. This study suggested that disopyramide and nifekalant should be feasible for the drug treatment of the SQTS. Moreover, QT interval was paradoxically prolonged at higher heart rates induced with isoproterenol infusion or an exercise test, although the mechanism of this QT prolongation remains to be investigated. | | Language | eng | | Pub Type(s) | Case Reports
Journal Article
| | PubMed ID | 18834480 |
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