| Title | Cryptococcosis in Solid Organ Transplant Recipients: Current State of the Science. | | Author(s) | Singh N, Dromer F, Perfect JR, Lortholary O | | Institution | 1University of Pittsburgh, Pennsylvania; 2Duke University, Durham, North Carolina; and 3Institut Pasteur, Molecular Mycology Unit, National Reference Center for Mycoses and Antifungals, and 4Université Paris Descartes, Centre d'Infectiologie Necker Pasteur, Hôpital Necker-Enfants Malades, Paris, France. | | Source | Clin Infect Dis 2008 Oct 7. | | Abstract | Cryptococcosis remains a significant opportunistic infection in solid organ transplant recipients. Disease presentation and outcomes may be affected by, among other factors, the use of calcineurin inhibitor immunosuppressive agents. It is being increasingly recognized that rapid reversal of immunosuppression in transplant recipients treated for cryptococcosis incurs the risk of immune reconstitution inflammatory syndrome, which resembles worsening disease or relapse. This review summarizes the current state of knowledge regarding cryptococcosis in transplant recipients and highlights areas where future investigations are needed to further optimize outcomes for these patients. | | Language | ENG | | Pub Type(s) | JOURNAL ARTICLE
| | PubMed ID | 18840080 |
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