Protein contact dermatitis: allergens, pathogenesis, and management. Dermatitis : contact, atopic, occupational, drug : official journal of the American Contact Dermatitis Society, North American Contact Dermatitis Group [Dermatitis] Journal article | | Title | Protein contact dermatitis: allergens, pathogenesis, and management. | | Author(s) | Levin C, Warshaw E | | Institution | University of Minnesota-Dermatology, Mayo Mail Code 98, 420 Delaware St. SE, Minneapolis, MN 55455-0392, USA. cllevin@gmail.com | | Source | Dermatitis 2008 Sep-Oct; 19(5):241-51. | | Abstract | Protein contact dermatitis is an allergic skin reaction induced principally by proteins of either animal or plant origin. The clinical presentation is that of a chronic dermatitis, and it is often difficult to differentiate between allergic contact dermatitis and other eczematous dermatoses. One distinguishing clinical feature is that acute flares of pruritus, urticaria, edema, or vesiculation are noted minutes after contact with the causative substances. Additionally, the patch-test result is typically negative, and the scratch- or prick-test result is positive. The pathogenesis of protein contact dermatitis is unclear but may involve a type I (immunoglobulin E [IgE], immediate) hypersensitivity reaction, type IV (cell-mediated delayed) hypersensitivity reaction, and/or a delayed reaction due to IgE-bearing Langerhans' cells. Management involves avoidance of the allergen. | | Language | eng | | Pub Type(s) | Journal Article
| | PubMed ID | 18845114 |
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