| Title | Efficacy and safety of sodium hyaluronate in the treatment of Wilkes stage II disease. | | Author(s) | Oliveras-Moreno JM, Hernandez-Pacheco E, Oliveras-Quintana T, Infante-Cossio P, Gutierrez-Perez JL | | Institution | Department of Oral and Maxillofacial Surgery, Virgen del Rocio University Hospital, Faculty of Dentistry, University of Seville, Seville, Spain. | | Source | J Oral Maxillofac Surg 2008 Nov; 66(11):2243-6. | | MeSH | Acetaminophen
Administration, Oral
Adult
Aged
Arthralgia
Drug Combinations
Drug Toxicity
Facial Pain
Female
Humans
Hyaluronic Acid
Injections, Intra-Articular
Male
Methocarbamol
Middle Aged
Pain Measurement
Pilot Projects
Range of Motion, Articular
Temporomandibular Joint Disorders
| | Abstract | PURPOSE: To show whether an intra-articular (IA) infiltration of 1 mL sodium hyaluronate (SH) into the temporomandibular joint (TMJ) would significantly reduce pain and improve joint function in Wilkes stage II disease, compared with the oral administration of a combination of methocarbamol and paracetamol.
PATIENTS AND METHODS: Forty-one patients with Wilkes stage II disease were selected and randomly assigned to 2 groups. The experimental group received 1 IA infiltration of SH with assessments at days 14, 28, 56, and 84. The control group was given 2 tablets of a combination of methocarbamol 380 mg and paracetamol 300 mg every 6 hours for 4 weeks, with assessments at days 14 and 28.
RESULTS: Forty-one patients were randomized into the study (SH: 20 patients, control drug: 21 patients). A statistically significant difference (P < . 05) was detected in favor of the SH group from day 56 onward for TMJ pain at rest, from day 14 onward for pain on jaw opening, and at days 28 and 56 for pain on mastication. The TMJ function was statistically significantly (P < .05) better in the test group at all follow-up visits. The global evaluation of efficacy by both, the patients and investigators, was better for the test group. No adverse reactions were detected with SH.
CONCLUSIONS: An IA infiltration of SH showed better efficacy in reducing pain and improving joint function in Wilkes stage II disease, compared with the oral administration of methocarbamol-paracetamol tablets. | | Language | eng | | Pub Type(s) | Journal Article
Randomized Controlled Trial
| | PubMed ID | 18940487 |
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