| Title | Induced hypotension in orthognathic surgery: a comparative study of 2 pharmacological protocols. | | Author(s) | Farah GJ, de Moraes M, Filho LI, Pavan AJ, Camarini ET, Previdelli IT, Coelho L | | Institution | Department of Oral and Maxillofacial Surgery, Piracicaba Dental School, State University of Campinas, Piracicaba, Brazil. gujfarah@uol.com.br | | Source | J Oral Maxillofac Surg 2008 Nov; 66(11):2261-9. | | MeSH | Adolescent
Adrenergic alpha-Agonists
Adult
Anesthesia Recovery Period
Anesthesia, Dental
Anesthesia, General
Anesthesia, Intravenous
Anesthetics, Inhalation
Anesthetics, Intravenous
Blood Pressure
Clonidine
Dexmedetomidine
Female
Heart Rate
Humans
Hypotension, Controlled
Isoflurane
Male
Oral Surgical Procedures
Piperidines
| | Abstract | PURPOSE: The objective of this comparative study was to report on the use of 2 different pharmaceutical protocols involving 2 different anesthetic techniques (IV and balanced) to induce hypotension in patients submitted to orthognathic surgery by assessing the patients' intra- and postoperative physiologic response and hemodynamic stability.
PATIENTS AND METHODS: Twenty ASA I patients, between 17 and 44 years of age who had dental and skeletal deformities were subdivided into 2 groups: group I (clonidine associated to remifentanil), and group II (dexmedetomidine associated to isoflurane), in addition, other drugs were common to both groups. The following responses were assessed: arterial blood pressure, heart rate, temperature during intra- and postoperative periods, incidence of nausea and vomiting, postoperative pain, awakening time, extubation time, and postanesthetic recovery time.
RESULTS: The results of the study using Repeated Measures Test statistical analysis showed that there were no significant differences between the 2 groups in respect to physiologic responses or surgery time.
CONCLUSION: Both protocols tried in this study proved to be effective and safe, and they seem to be interesting alternatives in longer orthognathic surgeries with the expectation of an important blood loss. The choice for either protocol should be based on the inherent risks involved in their use and their cost-benefit ratio. | | Language | eng | | Pub Type(s) | Journal Article
Randomized Controlled Trial
| | PubMed ID | 18940490 |
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