Jalal IM, Sa'sa' SI
Simultaneous determination of dextropropoxyphene napsylate, caffeine, aspirin and salicylic acid in pharmaceutical preparations by reversed-phase HPLC. [Journal Article]
Talanta 1984 Nov; 31(11):1015-7.
The official compendial method for the determination of dextropropoxyphene napsylate, caffeine, aspirin and salicylic acid involves a lengthy extraction by gas chromatography and spectrophotometry. The analytical scheme reported here provides a fast, sensitive, and stability-indicating reversed-phase HPLC assay for all these components concurrently. The total elution time is 10 min. The accuracy of the method has been tested on commercial products. The method can easily detect low levels of salicylic acid.
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