| Title | A comparative study using HPLC and packed column supercritical fluid chromatography for the assay of three anti-psychotic dosage forms. | | Author(s) | Patela YP, Dhorda UJ, Sundaresan M | | Institution | Ismail Yusuf College of Arts, Science and Commerce, Jogeshwari (East), Mumbai 400 060, India. | | Source | Talanta 1998 Nov; 47(3):625-30. | | Abstract | A reproducible and selective method was developed for the analysis of three anti-pschycotics, i.e. haloperidol, trifluoperazine and trihexyphenidyl in bulk and dosage forms using packed column supercritical fluid chromatography (SFC). The analytes were resolved by elution with supercritical fluid carbon dioxide doped with 16.67% (v/v) methanol containing 0.8% isopropylamine. Parallel studies were performed by HPLC using ion pairing reagent and a comparison is discussed. The method was successfully used for the assay of three formulations containing a combination of: (1) haloperidol-trihexyphenidyl; (2) haloperidol-trifluoperazine; (3) trifluoperazine-trihexyphenidyl. | | Language | eng | | Pub Type(s) | Journal Article
| | PubMed ID | 18967364 |
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