Popović GV, Pfendt LB, Moskovljević VM Derivative spectrophotometric method for determination of acidity constants of single step acid-base equilibria. [Journal Article] Talanta 2001 Aug 30; 55(2):363-70.
A general derivative spectrophotometric method for determination of acidity constants is developed. The method appears suitable in cases when classical spectrophotometry cannot be employed due to little differences in the absorption spectra of conjugated acid-base pairs. Based on theoretical considerations, seven variants of the method have been established and their validity was checked, determining acidity constants of lorazepam and flurazepam as model compounds.
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