Determination of Clobazam, Clorazepate, Flurazepam and Flunitrazepam in pharmaceutical preparations. Talanta [Talanta] Journal article | | Title | Determination of Clobazam, Clorazepate, Flurazepam and Flunitrazepam in pharmaceutical preparations. | | Author(s) | Berzas JJ, Castañeda G, Pinilla MJ | | Institution | Departamento de Quimica Analitica y Tecnologia de Alimentos, Facultad de Quimicas, Universidad de Castilla-La Mancha, 13071 Ciudad Real, Spain. | | Source | Talanta 2002 May 16; 57(2):333-41. | | Abstract | The separation of four benzodiazepines (Flurazepam, Flunitrazepam, Clobazam and Clorazepate) in pharmaceutical products by micellar electrokinetic chromatography (MEKC) is described. It was carried out at 25 degrees C and 25 kV by using a 57 cm (50 cm to the detector)x75 mum i.d. fused silica capillary and a 15 mM borate buffer (pH 9.2), 35 mM sodium dodecylsulfate (SDS) and 35 mM sodium deoxycholate water solution. Under these conditions, the analysis was performed in 8 min with acceptable limits of quantification (between 3 and 5 mg l(-1)). The method has been applied for quantifying these benzodiazepines in serum and different commercial formulations with recoveries near 100%. | | Language | eng | | Pub Type(s) | Journal Article
| | PubMed ID | 18968634 |
|
|
| |
Advertise on this site.
| | |
|
