| Title | Protective effect of vitamin C on oxidative stress: a randomized controlled trial. | | Author(s) | Sasazuki S, Hayashi T, Nakachi K, Sasaki S, Tsubono Y, Okubo S, Hayashi M, Tsugane S | | Institution | Epidemiology and Prevention Division, Research Center for Cancer Prevention and Screening National Cancer Center, 5-1-1 Tsukiji, Chuo-ku, Tokyo 104-0045, Japan, ssasazuk@gan2.res.ncc.go.jp. | | Source | Int J Vitam Nutr Res 2008 May; 78(3):121-8. | | Abstract | Background: Although a number of reports regarding the role of reactive oxygen species (ROS) as the first step in cancer induction exist, few studies have investigated how vitamin C influences ROS in human plasma. Aim of the study: Using the ROS assay system, a method recently established by one of the authors, we aimed to evaluate the effect of vitamin C supplementation on serum ROS among subjects diagnosed with chronic gastritis.
Methods: A total of 244 Japanese subjects with atrophic gastritis were randomized to take 5-year supplementation of either 50 mg or 500 mg of vitamin C.
Results: The adjusted difference in the changes of total ROS between baseline and after 5-year supplementation was statistically significant between the intervention groups: 2.70 decrease (corresponds to 1.26% decrease) in the high-dose group and 4.16 increase (corresponds to 3.79% increase) in the low-dose group, p for difference = 0.01.
Conclusion: Vitamin C was suggested to reduce oxidative stress among subjects with atrophic gastritis. | | Language | eng | | Pub Type(s) | Journal Article
| | PubMed ID | 19003734 |
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