Effect of tacrine, amiridine, akatinol memantine, and triazolam on phosphorylation, structure, and assembly of microtubules from brain microtubular proteins in Alzheimer diseases. Bulletin of experimental biology and medicine [Bull Exp Biol Med] Journal article | | Title | Effect of tacrine, amiridine, akatinol memantine, and triazolam on phosphorylation, structure, and assembly of microtubules from brain microtubular proteins in Alzheimer diseases. | | Author(s) | Shevtsov PN, Shevtsova EF, Burbaeva GSh | | Institution | Laboratory of Neurochemistry, Research Center of Mental Health, Russian Academy of Medical Sciences, Moscow. shevt@dio.ru | | Source | Bull Exp Biol Med 2008 Feb; 145(2):218-22. | | Abstract | In in vitro experiments, amiridine in concentration of 100, 200, and 300 microM restored disturbed structure of microtubules assembled from tubulin and microtubule-associated proteins isolated from the brain of patients with Alzheimer disease. Tacrine in a concentration of 100, 250, and 500 microM inhibited phosphorylation of tubulin and microtubule-associated proteins isolated from the brain of patients with Alzheimer disease, while memantine and amiridine in the specified concentrations had no effect on phosphorylation. | | Language | eng | | Pub Type(s) | Journal Article
| | PubMed ID | 19023973 |
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