Drebushchak TN, Chukanov NV, Boldyreva EV
Two polymorphs of chlorpropamide: the delta-form and the high-temperature -form. [JOURNAL ARTICLE]
Acta Crystallogr C 2008 Dec 15; 64(Pt 12):o623-o625.
The -form of chlorpropamide [systematic name: 4-chloro-N-(propylaminocarbonyl)benzenesulfonamide], C(10)H(13)ClN(2)O(3)S, has been obtained as single crystals from solution (and not as a polycrystalline sample by heating the alpha-, gamma- or delta-forms). The results of anisotropic structure refinements for the - and delta-forms are reported. The density of the delta-polymorph is the highest, and that of the -polymorph the lowest, among the five known chlorpropamide polymorphs. The main intermolecular hydrogen-bonding pattern in polymorphs delta and is the same as in polymorphs alpha, beta and gamma, but the conformations differ. The densities of the polymorphs were found to depend on the molecular conformations.
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