| Title | Antisickling properties of divanilloylquinic acids isolated from Fagara zanthoxyloides Lam. (Rutaceae). | | Author(s) | Ouattara B, Jansen O, Angenot L, Guissou IP, Frédérich M, Fondu P, Tits M | | Institution | Institut de Recherche en Sciences de la Santé (IRSS), Département Médecine Pharmacopée Traditionnelle, Pharmacie 03 BP 7192 Ouagadougou 03, Burkina Faso; Université Libre de Bruxelles, Institut de Pharmacie, B-1050 Bruxelles, Belgium. | | Source | Phytomedicine 2008 Dec 23. | | Abstract | Fagara zanthoxyloides Lam. (syn. Zanthoxylum zanthoxyloides) (Rutaceae) is the most cited Fagara species for the treatment and the prevention of sickle cell disease crisis. Sickle cell anemia (SCA) is a public health problem in many countries particularly in Africa. The present study was designed to evaluate the antisickling properties of three isomeric divanilloylquinic acids (3,4-O-divanilloylquinic acid or burkinabin A; 3,5-O-divanilloylquinic acid or burkinabin B and 4,5-O-divanilloylquinic acid or burkinabin C) identified previously by LC/MS/NMR analysis in the root bark of F. zanthoxyloides [Ouattara et al., 2004. LC/MS/NMR analysis of isomeric divanilloylquinic acids from the root bark of Fagara zanthoxyloides Lam. Phytochemistry 65, 1145-1151]. The three isomers showed interesting antisickling properties which increased from burkinabins A to C. | | Language | ENG | | Pub Type(s) | JOURNAL ARTICLE
| | PubMed ID | 19110407 |
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