| Title | Rhodotorula spp. isolated from blood cultures: clinical and microbiological aspects. | | Author(s) | De Almeida GM, Costa SF, Melhem M, Motta AL, Szeszs MW, Miyashita F, Pierrotti LC, Rossi F, Burattini MN | | Institution | Microbiology Laboratory, Division of Central Laboratory, LIM 03 Department of Pathology, University of São Paulo, São Paulo, Brazil. gmduboc@hcnet.usp.br | | Source | Med Mycol 2008 Sep; 46(6):547-56. | | MeSH | Adolescent
Adult
Aged
Amphotericin B
Antifungal Agents
Brazil
Candidiasis
Child
Child, Preschool
Female
Follow-Up Studies
Fungemia
Humans
Male
Microbial Sensitivity Tests
Middle Aged
Retrospective Studies
Rhodotorula
Young Adult
| | Abstract | The emergence of less common fungal pathogens has been increasingly reported in the last decade. We describe 25 cases of Rhodotorula spp. isolated from blood cultures at a large Brazilian tertiary teaching hospital from 1996-2004. We also investigated the in vitro activity of four antifungal drugs, using a standardized method. The median age of patients was 43 years. The majority of patients (88%) had a central venous catheter (CVC) and 10 (40%) were recipients of a bone marrow transplant. The episode was classified as a bloodstream infection (BSI) in 80% of the patients. Amphotericin B deoxycholate was the most common antifungal used and CVC was removed in 89.5% of the patients. Death occurred in four patients (17.4%), all classified as BSI. All strains were identified as R. mucilaginosa by conventional methods. Misidentification of the species was observed in 20% and 5% of the strains with the Vitek Yeast Biochemical Card and API 20C AUX systems, respectively. Amphotericin B demonstrated good in vitro activity (MIC50/90, 0.5 microg/ml) and the MICs for fluconazole were high for all strains (MIC50/90, >64 microg/ml). | | Language | eng | | Pub Type(s) | Journal Article
| | PubMed ID | 19180725 |
|
