| Title | Pregnancy-associated thrombotic thrombocytopenic purpura. | | Author(s) | Gerth J, Schleussner E, Kentouche K, Busch M, Seifert M, Wolf G | | Institution | Department of Internal Medicine III, University Hospital Jena, Erlanger Allee 101, D-07740 Jena, Germany. | | Source | Thromb Haemost 2009 Feb; 101(2):248-51. | | MeSH | ADAM Proteins
Autoantibodies
Blood Component Transfusion
Cesarean Section
Female
Gestational Age
Humans
Infant, Newborn
Live Birth
Male
Patient Care Team
Plasmapheresis
Platelet Count
Pregnancy
Pregnancy Complications, Hematologic
Purpura, Thrombotic Thrombocytopenic
Ultrasonography, Doppler, Color
Ultrasonography, Prenatal
Young Adult
von Willebrand Factor
| | Abstract | Thrombocytopenia during pregnancy is a common diagnostic and management problem. Several differential diagnosis must be considered including manifestations of thrombotic thrombocytopenic purpura (TTP). We report here on a case of a 21-year-old pregnant woman who presented initially severe thrombocytopenia (8 Gpt/l) in the 20(th)+1 week of gestation. The patient had an antibody against ADAMTS13, and enzyme activity was <5%. Immediate plasmapheresis treatment was initiated, followed by plasma infusions, and again plasmapheresis. A male neonate was delivered by caesarean section in the 32(nd )week of gestation. The child had an uncomplicated postnatal development. After delivery, the mother's platelet count and ADAMTS13 activity increased to normal values. This case shows interesting aspects of TTP in pregnancy and a close cooperation between obstetricians, nephrologists and pediatricians is necessary for a successful outcome of the pregnancy. | | Language | eng | | Pub Type(s) | Case Reports
Journal Article
| | PubMed ID | 19190806 |
|
