Association of VEGF polymorphisms with childhood asthma, lung function and airway responsiveness. The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology [Eur Respir J] Journal article | | Title | Association of VEGF polymorphisms with childhood asthma, lung function and airway responsiveness. | | Author(s) | Sharma S, Murphy AJ, Soto-Quiros ME, Avila L, Klanderman BJ, Sylvia JS, Celedón JC, Raby BA, Weiss ST | | Institution | Department of Medicine, Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Channing Laboratory, Harvard Medical School, Boston, MA 02115, USA. ssharma4@partners.org | | Source | Eur Respir J 2009 Jun; 33(6):1287-94. | | MeSH | Adolescent
Adrenal Cortex Hormones
Anti-Asthmatic Agents
Asthma
Bronchial Provocation Tests
Child
Costa Rica
Double-Blind Method
European Continental Ancestry Group
Female
Forced Expiratory Volume
Genotype
Haplotypes
Humans
Male
Nedocromil
Phenotype
Placebos
Polymorphism, Single Nucleotide
Regression Analysis
Respiratory Function Tests
Software
Vascular Endothelial Growth Factor A
Vital Capacity
| | Abstract | Vascular endothelial growth factor (VEGF) is an angiogenic factor implicated in asthma severity. The objective of the present study was to determine whether VEGF single nucleotide polymorphisms (SNPs) are associated with asthma, lung function and airway responsiveness. The present authors analysed 10 SNPs in 458 white families in the Childhood Asthma Management Program (CAMP). Tests of association with asthma, lung function and airway responsiveness were performed using PBAT software (Golden Helix, Inc. Bozeman, MT, USA; available at www.goldenhelix.com). Family and population-based, revpeated measures analysis of airflow obstruction were conducted. Replication studies were performed in 412 asthmatic children and their parents from Costa Rica. Associations with asthma, lung function and airway responsiveness were observed in both cohorts. SNP rs833058 was associated with asthma in both cohorts. This SNP was also associated with increased airway responsiveness in both populations. An association of rs4711750 and its haplotype with forced expiratory volume in 1 s (FEV(1))/forced vital capacity (FVC) ratio in both cohorts was observed. Longitudinal analysis in CAMP confirmed an association of rs4711750 with FEV(1)/FVC decline over approximately 4.5 yrs of observation. VEGF polymorphisms are associated with childhood asthma, lung function and airway responsiveness in two populations, suggesting that VEGF polymorphisms influence asthma susceptibility, airflow obstruction and airways responsiveness. | | Language | eng | | Pub Type(s) | Journal Article
Multicenter Study
Randomized Controlled Trial
Research Support, N.I.H., Extramural
| | PubMed ID | 19196819 |
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