| Title | Reduction of intraocular pressure with anecortave acetate in eyes with ocular steroid injection-related glaucoma. | | Author(s) | Robin AL, Suan EP, Sjaarda RN, Callanan DG, Defaller J, Alcon Anecortave Acetate for IOP Research Team | | Institution | Bloomberg School of Public Health and Wilmer Institute, Johns Hopkins University, Baltimore, Maryland, USA. arobin@glaucomaexpert.com | | Source | Arch Ophthalmol 2009 Feb; 127(2):173-8. | | MeSH | Adult
Aged
Aged, 80 and over
Antihypertensive Agents
Delayed-Action Preparations
Female
Glucocorticoids
Humans
Injections
Intraocular Pressure
Male
Middle Aged
Ocular Hypertension
Pregnadienediols
Prospective Studies
Retinal Diseases
Tonometry, Ocular
Triamcinolone Acetonide
Vitreous Body
| | Abstract | OBJECTIVE: To evaluate the intraocular pressure (IOP)-lowering potential of anecortave acetate (AA) in eyes with steroid-related ocular hypertension inadequately controlled with the maximal tolerated or appropriate medical therapy.
DESIGN: Uncontrolled case series.
METHODS: A total of 8 eyes of 7 subjects with medically uncontrolled IOP following intravitreal or sub-Tenon injections of triamcinolone acetonide were included. All received an 0.8-mL anterior juxtascleral depot of 3% AA solution (24 mg) under topical anesthesia. The IOP was assessed weekly for the first month, then monthly for a minimum of 1 year.
RESULTS: The mean baseline IOP was 39.9 mm Hg. After 1 week, the mean IOP decreased 12 mm Hg (29%; P = .005) and by 1 month, the mean IOP had decreased 14.1 mm Hg (34.5%; P = .003) from baseline. Four eyes required surgical intervention despite a decrease in IOP because of markedly elevated initial IOP and the degree of preexisting glaucomatous optic neuropathy. We observed no adverse events.
CONCLUSIONS: An anterior juxtascleral depot of AA lowers IOP substantially in some eyes with medically uncontrolled steroid-related ocular hypertension. Further study is warranted to clarify the role of AA in treating this condition as well as other forms of glaucoma. | | Language | eng | | Pub Type(s) | Journal Article
| | PubMed ID | 19204235 |
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