| Title | Combination of budesonide and aminophylline diminished acute lung injury in animal model of meconium aspiration syndrome. | | Author(s) | Mokra D, Drgova A, Mokry J, Bulikova J, Pullmann R, Durdik P, Petraskova M, Calkovska A | | Institution | Department of Physiology, Jessenius Faculty of Medicine, Comenius University, Martin, Slovakia. mokra@jfmed.uniba.sk | | Source | J Physiol Pharmacol 2008 Dec.:461-71. | | MeSH | Aminophylline
Animals
Animals, Newborn
Blood Pressure
Bronchodilator Agents
Budesonide
Humans
Immunoassay
Infant, Newborn
Injections, Intravenous
Leukocyte Count
Lipid Peroxidation
Lung Diseases
Meconium Aspiration Syndrome
Neutrophil Infiltration
Oxygen
Rabbits
Respiratory Function Tests
Thiobarbituric Acid Reactive Substances
Trachea
| | Abstract | Combination of low-dose budesonide and low-dose aminophylline may improve lung function in reduced adverse effects compared with high-dose monotherapy. Adult rabbits intratracheally received 4 ml/kg of saline or meconium (25 mg/ml). Meconium-injured rabbits were treated at 0.5 and 2.5 h after meconium instillation by intravenous aminophylline (1.0 mg/kg), by intratracheal budesonide (0.125 mg/kg) followed by intravenous aminophylline (1.0 mg/kg), or were untreated. Although aminophylline improved some respiratory parameters, budesonide+aminophylline more effectively reduced intrapulmonary shunts and improved gas exchange, without significant cardiovascular effects. Combined treatment reduced lung edema and number of lung neutrophils to a higher extent than aminophylline alone. Both treatments reduced lung peroxidation and in vitro airway reactivity to histamine, with a better effect after aminophylline alone. Combination of budesonide and aminophylline enhanced respiratory parameters more effectively, having fewer side effects than aminophylline alone. However, no additive effect of budesonide was observed on lung peroxidation and in vitro airway reactivity. | | Language | eng | | Pub Type(s) | Journal Article
Research Support, Non-U.S. Gov't
| | PubMed ID | 19218670 |
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