| Title | An exaggerated hypertensive response to glycopyrrolate therapy for bradycardia associated with high-dose dexmedetomidine. | | Author(s) | Mason KP, Zgleszewski S, Forman RE, Stark C, DiNardo JA | | Institution | Department of Anesthesia, Perioperative and Pain Medicine, Children's Hospital Boston and Harvard Medical School, Boston, MA 02115, USA. keira.mason@childrens.harvard.edu | | Source | Anesth Analg 2009 Mar; 108(3):906-8. | | Abstract | At our institution, high-dose i.v. dexmedetomidine is used to provide sedation for pediatric patients undergoing nonpainful radiological imaging studies. Some of these patients exhibit marked bradycardia (more than 20% deviation from the lowest age-adjusted normal values) while maintaining an arterial blood pressure within an acceptable normal range. We report on three cases wherein treatment of dexmedetomidine-induced bradycardia with i.v. glycopyrrolate (5.0 microg/kg) not only resulting in resolution of bradycardia but also resulting in an exaggerated increase of arterial blood pressure. | | Language | eng | | Pub Type(s) | Journal Article
| | PubMed ID | 19224802 |
|
