Oral signs of intravenous chemotherapy with 5- Fluorouracil and Leucovorin Calcium in colon cancer treatment. Medicina oral, patología oral y cirugía bucal [Med Oral Patol Oral Cir Bucal] Journal article | | Title | Oral signs of intravenous chemotherapy with 5- Fluorouracil and Leucovorin Calcium in colon cancer treatment. | | Author(s) | Mazzeo MA, Linares JA, Campos ML, Busamia BE, Dubersarsky C, Lavarda M, Jarchum G, Finkelberg AB | | Institution | Cátedra de Fisiología. Facultad de Odontología, Ciudad Universitaria, Córdoba, Argentina, finkelberg1@yahoo.com. | | Source | Med Oral Patol Oral Cir Bucal 2009 Mar; 14(3):E108-13. | | Abstract | Several studies have shown how cytostatics may cause salivary gland hypofunction. The aim of this study was to determine potential salivary gland disorders in patients treated with 5- Fluorouracil (5-Fu) and Leucovorin calcium (LV) as well as to examine the correlation with certain oral health disorders that diminish the quality of life. Materials and methods:this research was observational and longitudinal. Twenty-five patients with colon cancer were assessed. Clinical history, oral health indexes and basal or stimulated saliva samples were recorded.
Results: Basal and stimulated salivary flow dropped in the intermediate stage. Stimulated saliva pH decreased during treatment. Salivary, urea, sodium and potassium rose during the intermediate phase. Löe and Silness rates as well as simplified bleeding index increased during therapy but reverted by the end of treatment. Depth index of the vestibular gingival sulcus rose during the intermediate phase but did not return.
Conclusion: This treatment caused functional salivary gland disorders as evidenced by basal and stimulated hyposialia, and acidification of stimulated saliva pH during the intermediate phase. Increase in basal urea may be due to protein catabolism arising from plasma or glands. Variation in Na+ and K+ of basal saliva might be assumed to be a possible duct disorder. Recovery of bleeding and Löe and Silness rates may point to a transient inflammatory effect associated to a decrease in salivary flow. Increase in the depth rates of the periodontal vestibular sulcus could be correlated with a higher risk of periodontal disease. | | Language | eng | | Pub Type(s) | Journal Article
| | PubMed ID | 19242388 |
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