Search for MDR modulators: Design, syntheses and evaluations of N-substituted acridones for interactions with p-glycoprotein and Mg(2+). Bioorganic & medicinal chemistry [Bioorg Med Chem] Journal article | | Title | Search for MDR modulators: Design, syntheses and evaluations of N-substituted acridones for interactions with p-glycoprotein and Mg(2+). | | Author(s) | Singh P, Kaur J, Kaur P, Kaur S | | Institution | Department of Chemistry, Guru Nanak Dev University, Amritsar 143 005, India. | | Source | Bioorg Med Chem 2009 Feb 8. | | Abstract | By combining the structural features of acridone based anti-cancer drugs (like amsacrine) and MDR modulator propafenone, acridones with hydroxyl amine chain at N-10 have been designed and synthesized. These molecules exhibit appreciable interactions with p-gp and Mg(2+) indicating their suitability to modulate p-gp mediated multi drug resistance. | | Language | ENG | | Pub Type(s) | JOURNAL ARTICLE
| | PubMed ID | 19243953 |
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