| Title | Management of prehospital antiplatelet and anticoagulant therapy in traumatic head injury: a review. | | Author(s) | McMillian WD, Rogers FB | | Institution | Department of Pharmacotherapy, Fletcher Allen Health Care, University of Vermont College of Medicine, Burlington, VT 05401, USA. wes.mcmillian@vtmednet.org | | Source | J Trauma 2009 Mar; 66(3):942-50. | | MeSH | Aged
Anticoagulants
Brain Injuries
Cerebral Hemorrhage, Traumatic
Combined Modality Therapy
Critical Care
Deamino Arginine Vasopressin
Emergency Medical Services
Factor VIIa
Hematoma, Epidural, Cranial
Hematoma, Subdural
Hemostatics
Hospital Mortality
Humans
Middle Aged
Plasma
Platelet Aggregation Inhibitors
Platelet Transfusion
Protamines
Recombinant Proteins
Risk Factors
Vitamin K 1
| | Abstract | Trauma and emergency department clinicians encounter a growing number of patients admitted with traumatic head injury on prehospital antithrombotic therapies. These patients appear to be at increased risk of developing life-threatening intracranial hemorrhage. It is imperative that trauma clinicians understand the mechanism and duration of commonly prescribed outpatient antithrombotics in order to appropriately assess and treat patients who develop intracranial hemorrhage. This review summarizes current literature on the morbidity and mortality associated with premorbid non-steroidal anti-inflammatory drugs, aspirin, clopidogrel, warfarin, and heparinoids in the setting of traumatic head injury, and also examines the current strategies for reversal of these therapies. | | Language | eng | | Pub Type(s) | Journal Article
Review
| | PubMed ID | 19276776 |
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