| Title | Preparation and evaluation of miconazole nitrate-loaded solid lipid nanoparticles for topical delivery. | | Author(s) | Bhalekar MR, Pokharkar V, Madgulkar A, Patil N, Patil N | | Institution | AISSMS College of Pharmacy, Kennedy Road, Pune, India. mrb1570@yahoo.com | | Source | AAPS PharmSciTech 2009; 10(1):289-96. | | MeSH | Administration, Cutaneous
Antifungal Agents
Cadaver
Calorimetry, Differential Scanning
Chemistry, Pharmaceutical
Crystallography, X-Ray
Drug Carriers
Drug Compounding
Drug Stability
Fatty Acids
Gels
Glycerides
Humans
Kinetics
Miconazole
Nanoparticles
Particle Size
Polysorbates
Propylene Glycol
Skin
Skin Absorption
Solubility
Spectroscopy, Fourier Transform Infrared
Surface-Active Agents
Technology, Pharmaceutical
| | Abstract | The purpose of this study was to prepare miconazole nitrate (MN) loaded solid lipid nanoparticles (MN-SLN) effective for topical delivery of miconazole nitrate. Compritol 888 ATO as lipid, propylene glycol (PG) to increase drug solubility in lipid, tween 80, and glyceryl monostearate were used as the surfactants to stabilize SLN dispersion in the SLN preparation using hot homogenization method. SLN dispersions exhibited average size between 244 and 766 nm. All the dispersions had high entrapment efficiency ranging from 80% to 100%. The MN-SLN dispersion which showed good stability for a period of 1 month was selected. This MN-SLN was characterized for particle size, entrapment efficiency, and X-ray diffraction. The penetration of miconazole nitrate from the gel formulated using selected MN-SLN dispersion as into cadaver skins was evaluated ex-vivo using franz diffusion cell. The results of differential scanning calorimetry (DSC) showed that MN was dispersed in SLN in an amorphous state. The MN-SLN formulations could significantly increase the accumulative uptake of MN in skin over the marketed gel and showed a significantly enhanced skin targeting effect. These results indicate that the studied MN-SLN formulation with skin targeting may be a promising carrier for topical delivery of miconazole nitrate. | | Language | eng | | Pub Type(s) | Evaluation Studies
Journal Article
| | PubMed ID | 19294517 |
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