| Title | New antimicrobial molecules and new antibiotic strategies. | | Author(s) | Rodríguez de Castro F, Naranjo OR, Marco JA, Violán JS | | Institution | Servicio de Neumología, Hospital Universitario de Gran Canaria Dr. Negrín, Universidad de Las Palmas de Gran Canaria, Las Palmas, Spain. frodcasw@gobiernodecanarias.org | | Source | Semin Respir Crit Care Med 2009 Apr; 30(2):161-71. | | MeSH | Acetamides
Anti-Infective Agents
Cephalosporins
Community-Acquired Infections
Drug Design
Drug Resistance, Multiple, Bacterial
Drug Therapy, Combination
Fluoroquinolones
Humans
Ketolides
Lipopeptides
Oxazolidinones
Pneumonia, Bacterial
Practice Guidelines as Topic
beta-Lactams
| | Abstract | Drug options for treatment of infections are increasingly limited. The pharmaceutical industry has found it difficult to discover new antimicrobial agents, and only two novel classes of antibiotics, the oxazolidinones and the cyclic lipopeptides, have entered the market since the late 1960s. Few new agents have reached the market in the last decade with potential interest for community-acquired pneumonia (CAP) treatment, including linezolid (the first oxazolidinone in clinical use), new fluoroquinolones, cefditoren, ertapenem, and telithromycin. Agents currently in clinical development include other novel quinolones and ketolides, broad-spectrum cephalosporin derivatives, faropenem, several glycopeptides, and iclaprim. Other molecules are considered to be promising candidates for the future. In addition to the foregoing agents, alternative treatment approaches have also been introduced into clinical practice, which include the administration of the appropriate antimicrobials in a timely manner and the consideration of the pharmacokinetic-pharmacodynamic properties of the agent(s). | | Language | eng | | Pub Type(s) | Journal Article
Review
| | PubMed ID | 19296416 |
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