Acetazolamide as an adjunct to CPAP treatment: a case of complex sleep apnea in a patient on long-acting opioid therapy. Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine [J Clin Sleep Med] Journal article

Title	Acetazolamide as an adjunct to CPAP treatment: a case of complex sleep apnea in a patient on long-acting opioid therapy.
Author(s)	Glidewell RN, Orr WC, Imes N
Institution	Lynn Institute of the Rockies, 2500 N Circle Drive, Colorado Springs, CO 80909, USA. rglidewell@lhsi.net
Source	J Clin Sleep Med 2009 Feb 15; 5(1):63-4.
MeSH	Acetazolamide Administration, Cutaneous Administration, Oral Adult Analgesics, Opioid Carbonic Anhydrase Inhibitors Combined Modality Therapy Comorbidity Continuous Positive Airway Pressure Drug Administration Schedule Female Fentanyl Humans Hydrocodone Polysomnography Sleep Apnea, Central Sleep Apnea, Obstructive Tarsal Tunnel Syndrome
Abstract	A 41-year-old white woman on long-acting opioid therapy was diagnosed with moderate obstructive sleep apnea. On initiation of continuous positive airway pressure (CPAP), she manifested severe central apnea that was unresponsive to supplemental oxygen and interfered with CPAP titration. Acetazolamide, 250 mg, nightly at bedtime was initiated, and CPAP titration was repeated. On acetazolamide, optimal CPAP pressure was obtained with no manifestation of clinically significant central respiratory disturbance. This case suggests that acetazolamide may be an effective adjunct to positive airway pressure therapy in patients on long-acting opioids. A need exists for examination of acetazolamide in this capacity.
Language	eng
Pub Type(s)	Case Reports Journal Article
PubMed ID	19317383

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