| Title | Effect of parenteral administration of ivermectin and erythromycin on abomasal emptying rate in suckling calves. | | Author(s) | Afshari GR, Nouri M, Hassan EB, Mokhber-Dezfooli MR, Constable PD | | Institution | Department of Clinical Sciences, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran. | | Source | Am J Vet Res 2009 Apr; 70(4):527-31. | | MeSH | Abomasum
Animals
Animals, Suckling
Antiparasitic Agents
Blood Glucose
Cattle
Cross-Over Studies
Erythromycin
Gastric Emptying
Gastrointestinal Agents
Infusions, Parenteral
Ivermectin
Random Allocation
Time Factors
| | Abstract | OBJECTIVE-To evaluate the effect of parenteral administration of ivermectin and erythromycin on abomasal emptying rate in suckling calves. ANIMALS-6 male Holstein-Friesian calves < 15 days old. PROCEDURES-In a crossover study, calves were administered each of 3 treatments (control treatment, 2 mL of saline [0.9% NaCl] solution, IM; erythromycin, 8.8 mg/kg, IM; and ivermectin, 200 microg/kg, IV). Thirty minutes later, calves were bottle-fed 2 L of fresh cow's milk containing acetaminophen (50 mg/kg). Blood samples were collected from a jugular vein at various periods after suckling of milk. Abomasal emptying rate was assessed by use of the time to pharmacokinetically determined maximal plasma acetaminophen concentration.
RESULTS-Administration of erythromycin and ivermectin caused a significant increase in abomasal emptying rate, compared with results for the control treatment, as determined on the basis of time to maximal plasma acetaminophen concentration.
CONCLUSIONS AND CLINICAL RELEVANCE-Parenteral administration of erythromycin and ivermectin increased the abomasal emptying rate. The macrolide erythromycin can be an effective prokinetic agent in calves and other animals. Ivermectin is classified as a macrolide but has a number of structural differences from erythromycin. The clinical importance of a slight increase in abomasal emptying rate after IV administration of ivermectin remains to be determined because ivermectin is only labeled for SC, oral, and topical administration. | | Language | eng | | Pub Type(s) | Journal Article
| | PubMed ID | 19335110 |
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