| Title | Voltammetric analysis of N-containing drugs using the hanging galinstan drop electrode (HGDE). | | Author(s) | Channaa H, Surmann P | | Institution | Institute of Pharmacy, Free University of Berlin, Germany. | | Source | Pharmazie 2009 Mar; 64(3):161-5. | | Abstract | The electrochemical behaviour of several N-containing voltammetric active drugs such as 1,4-benzodiazepines (chlordiazepoxide, nitrazepam and diazepam) as well as one nitro-compound (nitrofurantoin) and one azo-compound (phenazopyridine) is described using a new kind of liquid electrode, the hanging galinstan drop electrode. Concentrations of 10(-5) - 10(-8) mol L(-1) are generally measurable. Differential pulse and adsorptive stripping voltammograms are recorded in different supporting electrolytes, like 0.1 M KNO3, acetate buffer solution pH = 4.6 and phosphate buffer solution pH = 7.0. The effects of varying the starting potentials, U(start) for DPV and accumulation times, t(acc) for AdSV are considered. Briefly, it is shown that the novel galinstan electrode is suitable for reducing several functional groups in organic substances, here presented for N-oxide-, azomethine-, nitro- and azo-groups. | | Language | eng | | Pub Type(s) | Journal Article
| | PubMed ID | 19348337 |
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