Miyara M, Wing K, Sakaguchi S
Therapeutic approaches to allergy and autoimmunity based on FoxP3+ regulatory T-cell activation and expansion. [Journal Article, Research Support, Non-U.S. Gov't, Review]
J Allergy Clin Immunol 2009 Apr; 123(4):749-55; quiz 756-7.
Forkhead box protein 3-positive regulatory T (Treg) cells are indispensable for the maintenance of self-tolerance and immune homeostasis. They can also be exploited for the treatment of immunologic diseases, including autoimmune diseases and allergy, by way of activating and expanding antigen-specific Treg cells in vivo. Cell therapy with in vitro activated and expanded Treg cells can be another therapeutic modality. The feasibility of such Treg cell-based therapeutic strategies is discussed based on recent advances in our understanding of the molecular and cellular basis of Treg cell development and function.
More from this journalRelated subjects (MeSH) |
