| Title | Therapeutic approaches to allergy and autoimmunity based on FoxP3+ regulatory T-cell activation and expansion. |
| Author(s) | Miyara M, Wing K, Sakaguchi S |
| Institution | Department of Experimental Pathology, Institute for Frontier Medical Sciences, Kyoto University, Kyoto, Japan. |
| Source | J Allergy Clin Immunol 2009 Apr; 123(4):749-55; quiz 756-7. |
| MeSH | Animals
Autoimmunity
Cytokines
Forkhead Transcription Factors
Humans
Hypersensitivity
Immune Tolerance
Immunotherapy
Lymphocyte Activation
Muromonab-CD3
T-Lymphocytes, Regulatory
|
| Abstract | Forkhead box protein 3-positive regulatory T (Treg) cells are indispensable for the maintenance of self-tolerance and immune homeostasis. They can also be exploited for the treatment of immunologic diseases, including autoimmune diseases and allergy, by way of activating and expanding antigen-specific Treg cells in vivo. Cell therapy with in vitro activated and expanded Treg cells can be another therapeutic modality. The feasibility of such Treg cell-based therapeutic strategies is discussed based on recent advances in our understanding of the molecular and cellular basis of Treg cell development and function. |
| Language | eng |
| Pub Type(s) | Journal Article
Research Support, Non-U.S. Gov't
Review
|
| PubMed ID | 19348913 |
