Park MY, Kwon HJ, Sung MK
Evaluation of Aloin and Aloe-Emodin as Anti-Inflammatory Agents in Aloe by Using Murine Macrophages. [JOURNAL ARTICLE]
Biosci Biotechnol Biochem 2009 Apr 7.
The aloe ingredients responsible for physiological effects and the concentrations required to exert their biological activities are not fully understood. This study compares the anti-inflammatory effects of aloin and aloe-emodin with other polyphenols. Our results demonstrated that aloe-emodin dose-dependently inhibited inducible nitric oxide synthase (iNOS) mRNA expression and nitric oxide (NO) production at 5-40 muM. In addition, the levels of cyclooxygenase-2 (COX-2) mRNA and prostaglandin E(2) (PGE(2)) production were suppressed by 40 muM aloe-emodin. Aloin also suppressed the production of NO at 5-40 muM, although it did not suppress PGE(2) production. The present results indicate that aloin and aloe-emodin possibly suppress the inflammatory responses by blocking iNOS and COX-2 mRNA expression. The anti-inflammatory effect of aloe-emodin was comparable to that of kaempferol and quercetin, indicating aloe-emodin as a possible key constituent responsible for the anti-inflammatory activity of aloe.
More from this journal |
