Evaluation of Aloin and Aloe-Emodin as Anti-Inflammatory Agents in Aloe by Using Murine Macrophages. Bioscience, biotechnology, and biochemistry [Biosci Biotechnol Biochem] Journal article | | Title | Evaluation of Aloin and Aloe-Emodin as Anti-Inflammatory Agents in Aloe by Using Murine Macrophages. | | Author(s) | Park MY, Kwon HJ, Sung MK | | Institution | Department of Food and Nutrition, Sookmyung Women's University. | | Source | Biosci Biotechnol Biochem 2009 Apr 7. | | Abstract | The aloe ingredients responsible for physiological effects and the concentrations required to exert their biological activities are not fully understood. This study compares the anti-inflammatory effects of aloin and aloe-emodin with other polyphenols. Our results demonstrated that aloe-emodin dose-dependently inhibited inducible nitric oxide synthase (iNOS) mRNA expression and nitric oxide (NO) production at 5-40 muM. In addition, the levels of cyclooxygenase-2 (COX-2) mRNA and prostaglandin E(2) (PGE(2)) production were suppressed by 40 muM aloe-emodin. Aloin also suppressed the production of NO at 5-40 muM, although it did not suppress PGE(2) production. The present results indicate that aloin and aloe-emodin possibly suppress the inflammatory responses by blocking iNOS and COX-2 mRNA expression. The anti-inflammatory effect of aloe-emodin was comparable to that of kaempferol and quercetin, indicating aloe-emodin as a possible key constituent responsible for the anti-inflammatory activity of aloe. | | Language | ENG | | Pub Type(s) | JOURNAL ARTICLE
| | PubMed ID | 19352036 |
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