Does statin usage reduce the risk of corticosteroid-related osteonecrosis in renal transplant population? The Orthopedic clinics of North America [Orthop Clin North Am] Journal article | | Title | Does statin usage reduce the risk of corticosteroid-related osteonecrosis in renal transplant population? | | Author(s) | Ajmal M, Matas AJ, Kuskowski M, Cheng EY | | Institution | Department of Orthopaedic Surgery, Veterans Affairs Hospital, Vanderbilt University, 1310 24th Avenue South, Nashville, TN 37212, USA. | | Source | Orthop Clin North Am 2009 Apr; 40(2):235-9. | | MeSH | Adolescent
Adult
Aged
Cholesterol
Disease-Free Survival
Female
Femur Head Necrosis
Follow-Up Studies
Glucocorticoids
Graft Rejection
Humans
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Hypercholesterolemia
Incidence
Kidney Failure, Chronic
Kidney Transplantation
Male
Middle Aged
Prospective Studies
Risk Factors
Time Factors
Treatment Outcome
United States
Young Adult
| | Abstract | The relationship between corticosteroids and osteonecrosis is well known. Limited data suggest that statins modulate cholesterol metabolism and may protect against osteonecrosis. The authors analyzed their prospective renal transplant database to determine if statin usage reduces the incidence of corticosteroid-related osteonecrosis and identified 2,881 renal transplantation patients who met the entry criteria. Among 338 patients on statins, 15 (4.4%) developed osteonecrosis, versus 180 of 2,543 (7%) patients who were not on statins. Osteonecrosis-free survival was similar in patients with and without statin exposure. | | Language | eng | | Pub Type(s) | Comparative Study
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
| | PubMed ID | 19358908 |
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