| Title | Pharmacokinetic drug interactions of synthetic opiate analgesics. | | Author(s) | Armstrong SC, Wynn GH, Sandson NB | | Institution | Center for Geriatric Psychiatry, Tuality Forest Grove Hospital, Forest Grove, Ore., USA. | | Source | Psychosomatics 2009 Mar-Apr; 50(2):169-76. | | Abstract | Earlier reviews have covered pharmacokinetic drug interactions of natural and semi-synthetic opioid analgesics. This review will focus on the pharmacokinetic drug-drug interactions of methadone, propoxyphene, levomethadyl, meperidine, other phenylpiperidines (such as fentanyl), pentazocine, diphenoxylate, loperimide, and tramadol. The authors present an extensive review of the current literature. These drugs, with a few exceptions, are, at least partially, if not primarily, metabolized by the cytochrome P450 isoenzyme system (CYP) 3A4, and the action/interaction of these enzymes can have an effect on outcome. Therefore, these drugs are likely to produce drug-drug interactions when the CYP3A4 system is inhibited or induced. Knowledge of these drug-drug interactions is important because such interactions may decrease drug efficacy or result in adverse effects. | | Language | eng | | Pub Type(s) | Journal Article
| | PubMed ID | 19377028 |
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