| Title | Successful treatment with gemtuzumab ozogamicin monotherapy in a pediatric patient with resistant relapse of acute myeloid leukemia. | | Author(s) | Unal S, Cakir M, Kuşkonmaz B, Cetin M, Tuncer AM | | Institution | Department of Pediatrics, Hacettepe University Faculty of Medicine, Ankara, Turkey. | | Source | Turk J Pediatr 2009 Jan-Feb; 51(1):69-71. | | Abstract | There are few therapeutic options in relapsed or refractory acute myeloid leukemia patients. CD33 antigen is expressed on approximately 90% of myeloblasts, and gemtuzumab ozogamicin, as a monoclonal antibody directed against the CD33 surface antigen, may be a good target for these patients. Herein, we present a 15-year-old acute myeloid leukemia patient who was resistant at relapse and could achieve remission with gemtuzumab ozogamicin at a total dose of 9 mg/m2, divided into three doses and delivered to hematopoietic stem-cell transplantation; however, the patient relapsed in a short time without application of transplantation. | | Language | eng | | Pub Type(s) | Journal Article
| | PubMed ID | 19378895 |
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