| Title | Treatment of giardiasis in common marmosets (Callithrix jacchus) with tinidazole. | | Author(s) | Kramer JA, Hachey AM, Wachtman LM, Mansfield KG | | Institution | Harvard Medical School, New England Primate Research Center, Southborough, Massachusetts, USA. | | Source | Comp Med 2009 Apr; 59(2):174-9. | | MeSH | Animals
Antitrichomonal Agents
Callithrix
Feces
Giardia lamblia
Giardiasis
Humans
Monkey Diseases
Tinidazole
| | Abstract | Giardia intestinalis is a common protozoan parasite that can infect many laboratory animal primates, although its role as a contributor to the induction of gastrointestinal disease remains unclear. This study sought to investigate the prevalence of Giardia in a colony of common marmosets by using a Giardia antigen-capture assay and to address the possible eradication of this infection by using tinidazole, an antiprotozoal similar to metronidazole but requiring fewer doses. Among 31 colony marmosets, 13 (42%) were positive for Giardia. Two doses of oral tinidazole eliminated the infection in all animals. Repeat testing of the 13 Giardia-positive monkeys 1 y later showed that 11 remained negative and that treated animals had a significant increase in weight at 1 y. Giardia antigen is common in common marmoset feces, and treatment using oral tinidazole is possible and highly effective. | | Language | eng | | Pub Type(s) | Journal Article
Research Support, N.I.H., Extramural
| | PubMed ID | 19389310 |
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