Androgens and hair loss. Current opinion in endocrinology, diabetes, and obesity [Curr Opin Endocrinol Diabetes Obes] Journal article | | Title | Androgens and hair loss. | | Author(s) | Alsantali A, Shapiro J | | Institution | Department of Dermatology and Skin Science, University of British Columbia, British Columbia, Canada. | | Source | Curr Opin Endocrinol Diabetes Obes 2009 Jun; 16(3):246-53. | | Abstract | PURPOSE OF REVIEW: Androgenetic alopecia (AGA) or male pattern hair loss is a very common condition that has a significant psychosocial impact for patients. Many advances in the pathogenesis and treatment of AGA have been discovered recently. We discuss the pathogenesis and treatment of AGA.
RECENT FINDINGS: Wide genome analysis showed an association of AGA and chromosome 20pll in addition to androgen-receptor gene. Also, a locus on chromosome 3q26 was found to have a linkage with AGA. Dutasteride has been shown to be more effective than finasteride in the treatment of AGA but is not yet a recommended therapy. In an in-vitro study, a new topical liposomal finasteride formulation showed more than five-fold higher deposition of drug in skin than the corresponding plain drug solution.
SUMMARY: These recent developments in the field of AGA hold some promise and may play a role in the future management. | | Language | eng | | Pub Type(s) | Journal Article
| | PubMed ID | 19396986 |
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