| Title | Enantioselective Synthesis of (R)-Tolterodine via CuH-Catalyzed Asymmetric Conjugate Reduction. | | Author(s) | Yoo K, Kim H, Yun J | | Institution | Department of Chemistry and Institute of Basic Science, Sungkyunkwan University, Suwon 440-746, Korea. | | Source | J Org Chem 2009 Apr 27. | | Abstract | An efficient and highly enantioselective method for the preparation of (R)-tolterodine is described. The synthesis was performed by CuH-catalyzed asymmetric conjugate reduction of a beta,beta-diaryl-substituted unsaturated nitrile as a key step, which is prepared by a stereoselective hydroarylation of alkynenitrile with aryl boronic acid. The synthesis was accomplished without employing the protection-deprotection sequence. | | Language | ENG | | Pub Type(s) | JOURNAL ARTICLE
| | PubMed ID | 19397303 |
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