| Title | In vitro Inhibitory Effects of Disodium Cromoglycate on Ionic Transports Involved in Sickle Cell Dehydration. | | Author(s) | Bizumukama L, Ferster A, Gulbis B, Kumps A, Cotton F | | Institution | Laboratory of Medical Biochemistry, Institut de Pharmacie, Université Libre de Bruxelles, Bruxelles, Belgium. | | Source | Pharmacology 2009 Apr 25; 83(5):318-322. | | Abstract | Background: The antiallergic and antiasthmatic drug disodium cromoglycate (DSCG) has also demonstrated an activity against sickle cell disease, but the mechanism of this action still remains unknown.
Methods: Na(+) and K(+) fluxes were studied in red cells obtained from 9 patients affected with sickle cell disease in the absence or in the presence of 1 mM of DSCG and deoxygenated under an N(2) flow during up to 24 h.
Results: A significant inhibiting effect of DSCG on the intracellular K(+) exit and the Na(+) entry was observed.
Conclusion: These results demonstrate that DSCG partially inhibits the abnormal K(+) loss which is implicated in the dehydration of the sickle cell and the stimulation of sickling. | | Language | ENG | | Pub Type(s) | JOURNAL ARTICLE
| | PubMed ID | 19401631 |
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