| Title | Hydralazine-induced autoimmune disease: comparison to idiopathic lupus and ANCA-positive vasculitis. | | Author(s) | Yokogawa N, Vivino FB | | Institution | Division of Rheumatology, University of Pennsylvania, 3600 Spruce Street-507 Maloney Bldg, Philadelphia, PA, 19104-4283, USA, yokogawan@aol.com. | | Source | Mod Rheumatol 2009 May 8. | | Abstract | We report two cases of hydralazine-induced vasculitis with rare complications: pulmonary renal syndrome and digital gangrene. We also review 68 published cases of hydralazine-induced vasculitis. Hydralazine-induced vasculitis mimics idiopathic antineutrophil cytoplasmic antibody (ANCA)-positive vasculitis. However, it also produces other autoantibodies, such as antinuclear antibodies, antihistone antibodies, anti-dsDNA antibodies, and antiphospholipid antibodies. Patients with hydralazine-induced vasculitis typically have a more severe course than those with hydralazine-induced lupus, predominantly due to renal vasculitis, and require a more aggressive treatment. | | Language | ENG | | Pub Type(s) | JOURNAL ARTICLE
| | PubMed ID | 19424772 |
|
