| Title | Familial coexisting and colocalized psoriasis and vitiligo responding to alefacept. | | Author(s) | Al-Mutairi N, Al-Doukhi A | | Institution | Department of Dermatology, Farwaniya Hospital, Farwaniya, Kuwait. nalmut@usa.net | | Source | J Cutan Med Surg 2009 May-Jun; 13(3):172-5. | | MeSH | Adolescent
Biopsy
Dermatologic Agents
Diagnosis, Differential
Dose-Response Relationship, Drug
Family
Female
Follow-Up Studies
Genetic Predisposition to Disease
Humans
Injections, Intramuscular
Male
Middle Aged
Psoriasis
Recombinant Fusion Proteins
Skin
Time Factors
Vitiligo
| | Abstract | BACKGROUND: Psoriasis is an immune-mediated, chronic, inflammatory disease that significantly impairs both physical and emotional aspects of an individual's quality of life. Vitiligo leads to depigmentation of skin, in which some or all melanocytes in the interfollicular epidermis and occasionally those in the hair follicles are selectively destroyed. The coexistence of the two disorders is rarely seen.
OBJECTIVE: To report two cases of the rare coexistence of psoriasis and vitiligo in a family.
METHODS: After providing informed written consent, both patients were given alefacept 15 mg/kg weekly injections for 12 weeks. The patients were monitored both clinically and with all relevant laboratory investigations. These patients were then followed up once a month for 2 years.
RESULTS: Treatment with alefacept led to complete clearance of vitiligo along with the expected improvement in psoriasis. In the 2-year follow-up, vitiligo did not recur, although psoriasis relapsed and was appropriately treated.
CONCLUSION: Use of alefacept in vitiligo may turn out to be a possible novel off-label treatment option in vitiligo. But the results need to be reproduced in larger studies. | | Language | eng | | Pub Type(s) | Case Reports
Journal Article
| | PubMed ID | 19426629 |
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