| Title | Atypical paraneoplastic pemphigus secondary to endometrial carcinoma with no mucosal involvement. | | Author(s) | Kennedy NA, Dawe S | | Institution | Flinders Medical Centre, SA, Australia. | | Source | Clin Exp Dermatol 2009 May 5. | | Abstract | Summary Paraneoplastic pemphigus (PNP) is a mucocutaneous immunobullous disease associated with several types of internal malignancy. We report a case of a 78-year-old woman presenting with an atypical form of PNP associated with a recurrence of endometrial cancer. There was no involvement of the mucous membranes. Although the macroscopic and histological appearances were typical for IgA pemphigus or Sneddon-Wilkinson disease, direct immunofluorescence was positive for intercellular IgG and C3 staining. Circulating antibodies were detected to periplakin and envoplakin, but not to desmogleins 1 or 3. This case therefore meets the modified criteria for PNP. A response was seen to a combination of topical and systemic corticosteroids and acitretin, although with cyclical recurrences. These ceased after resection of her recurrent endometrial carcinoma. | | Language | ENG | | Pub Type(s) | JOURNAL ARTICLE
| | PubMed ID | 19438579 |
|
