| Title | The VYtorin on Carotid intima-media thickness and overall arterial rigidity (VYCTOR) study. | | Author(s) | Meaney A, Ceballos G, Asbun J, Solache G, Mendoza E, Vela A, Meaney E | | Institution | Cardiovascular Unit, Regional Hospital, 1 de Octubre, ISSSTE, Mexico. ameaney@cinvestav.mx | | Source | J Clin Pharmacol 2009 Jul; 49(7):838-47. | | MeSH | Adult
Aged
Anticholesteremic Agents
Azetidines
Blood Pressure
Body Mass Index
C-Reactive Protein
Carotid Artery, Internal
Cholesterol
Coronary Disease
Drug Combinations
Drug Therapy, Combination
Female
Humans
Male
Middle Aged
Simvastatin
Triglycerides
Tunica Intima
Tunica Media
| | Abstract | This study assessed the effect of 3 lipid-lowering therapies on the reduction of the carotid intima-media thickness (IMT) in high-risk coronary Mexican patients. The study was a randomized, comparative, and open clinical trial. Ninety high-risk coronary patients were allocated to 3 groups: pravastatin 40 mg, simvastatin 40 mg, and simvastatin 20 mg and ezetimibe 10 mg initially. If the therapeutic goals were not attained (<100 mg/dL of low-density lipoprotein cholesterol [LDL-C] for type C and <70 mg for type D), patients in group 1 received pravastatin 40 mg and ezetimibe 10 mg, group 2 received simvastatin 80 mg, and group 3 received simvastatin 40 mg and ezetimibe 10 mg. The primary endpoint was the change of IMT over the course of 1 year. The secondary endpoints were changes in LDL-C and in high sensitive C-reactive protein (CRPhs). The overall baseline IMTs generated by combining measurements in the internal carotid artery were 1.33+/-0.32 mm, 1.30+/-0.11 mm, and 1.23+/-0.28 mm for groups 1, 2, and 3, respectively. After 1 year, IMT values were 0.93+/-0.13 mm, 0.90+/-0.11 mm, and 0.92+/-0.01 mm for groups 1, 2, and 3, respectively. At the end of the study, LDL-C levels were 48+/-41, 45+/-37, and 48+/-31 in groups 1, 2, and 3, respectively. No significant differences were observed in CRP, high-density lipoprotein cholesterol, triglycerides, blood pressure, and body mass index, among the groups. This study is one of the first providing evidence that dual therapy has a beneficial effect on a surrogate marker of atherosclerosis. | | Language | eng | | Pub Type(s) | Comparative Study
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't
| | PubMed ID | 19443679 |
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