Electrostatically Mediated Liposome Fusion and Lipid Exchange with a Nanoparticle-Supported Bilayer for Control of Surface Charge, Drug Containment, and Delivery. Journal of the American Chemical Society [J Am Chem Soc] Journal article | | Title | Electrostatically Mediated Liposome Fusion and Lipid Exchange with a Nanoparticle-Supported Bilayer for Control of Surface Charge, Drug Containment, and Delivery. | | Author(s) | Liu J, Jiang X, Ashley C, Brinker CJ | | Institution | Center for Micro-Engineered Materials, Department of Chemical and Nuclear Engineering, and Department of Molecular Genetics and Microbiology, University of New Mexico, and Sandia National Laboratories, Albuquerque, New Mexico 87106. | | Source | J Am Chem Soc 2009 May 15. | | Abstract | The loading and containment of cargo within nanoparticles and their efficient delivery to cells represent a primary challenge in nanomedicine. We report lipid exchange between free and mesoporous silica nanoparticle-supported lipid bilayers as an effective means of containing cargo, controlling charge, and directing delivery to mammalian cells. The delivery of a membrane-impermeable dye (calcein) and a chemotherapeutic drug (doxorubicin) are demonstrated. Exchanged lipid bilayers minimized premature drug release, and an overall positive charge on the supported lipid bilayer effected enhanced delivery. | | Language | ENG | | Pub Type(s) | JOURNAL ARTICLE
| | PubMed ID | 19445508 |
|
|
| |
Advertise on this site.
| | |
|
