Expression of Gonadotropin alpha, Follicle-stimulating Hormone beta, and Luteinizing Hormone beta Genes of the Hermaphroditic Fish Kryptolebias marmoratus Exposed to Octylphenol, 17beta Estradiol, and Tamoxifen. Annals of the New York Academy of Sciences [Ann N Y Acad Sci] Journal article | | Title | Expression of Gonadotropin alpha, Follicle-stimulating Hormone beta, and Luteinizing Hormone beta Genes of the Hermaphroditic Fish Kryptolebias marmoratus Exposed to Octylphenol, 17beta Estradiol, and Tamoxifen. | | Author(s) | Rhee JS, Lee YM, Seo JS, Han J, Lee JS | | Institution | Department of Molecular and Environmental Bioscience, Graduate School, Hanyang University, Seoul, Korea. | | Source | Ann N Y Acad Sci 2009 Apr.:508-11. | | Abstract | In order to study the expression of the gonadotropin alpha subunit and beta subunit [follicle-stimulating hormone (FSH)-beta and luteinizing hormone (LH)-beta] cDNAs in the hermaphroditic fish Kryptolebias marmoratus, we cloned these genes and analyzed their modulatory effects in the brain/pituitary tissue after exposure to 17beta estradiol (E2), tamoxifen (TMX), and octyphenol. Gonadotropin beta subunit (FSH-beta and LH-beta) showed E2-dependent upregulation in most hermaphrodites, whereas TMX did not show elevated expression. Octyphenol also showed a similar effect of upregulation on FSH-beta expression but not for the LH-beta gene. These results suggest that the expression of FSH-beta and LH-beta in K. marmoratus is associated with their expression on endocrine-disrupting chemicals in this species. | | Language | eng | | Pub Type(s) | Journal Article
| | PubMed ID | 19456401 |
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