Kauffman MA, Yankilevich P, Barrero P, Bello R, Marangunich L, Vidal A, Criscuolo M, Diez RA, Sterin Prync A
Whole genome analysis of the action of interferon-beta. [Journal Article]
Int J Clin Pharmacol Ther 2009 May; 47(5):328-57.
Objectives: To characterize the IFNbeta1a-regulated gene expression on leukocytes of Multiple Sclerosis (MS) patients using microarrays with whole human genome representation.
Methods: Genes differentially expressed by interferon-beta were identified by a microarray in vitro study performed in leukocytes obtained from 5 MS relapsing-remitting patients.
Results: Following the culture of peripheral blood mononuclear cells from MS relapsing-remitting patients for 24 hs with IFNbeta1a, the expression of 868 genes was modified: 545 increased (including CXCL11, CCL8, INDO, IFI27, CFB, CXCL10 and IFIT1) and 323 diminished (including RBP7, SEPT5, RNF8, ADORA2B and FOS).
Conclusions: Since many of them were previously recognized as involved in MS pathogenesis, the IFNbeta1a mechanism of action could imply a compensatory regulation of systems deregulated in MS.
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